Medgyl

Manufacturer	Medhaus
Distributor	Medhaus
Contents	Metronidazole
Indications	Treatment of susceptible protozoal infections eg amoebiasis, balantidiasis, Blastocystis hominis infections, giardiasis & trichomoniasis. It has also been tried in leishmaniasis & microsporidiosis.
Dosage	Adult 400-800 mg tid for 5-10 days. Childn 7-10 yr 35-50 mg/kg body wt/day in divided doses, 3 yr 1/3 adult dose, 1-3 yr ¼ adult dose.
Administration	susp:Should be taken on an empty stomach (Take at least 1 hr before meals.); tab:Should be taken with food.
Contraindications	Lactation.
Special Precautions	Patients w/ blood dyscrasias or w/ active disease of the CNS, severe liver disease. Avoid prolonged use. Discontinue treatment if peripheral neuropathy or CNS toxicity occur. Pregnancy, esp 1st trimester.
Adverse Drug Reactions	GI disturbances, headache, anorexia, vomiting, diarrhea, dry mouth, furred tongue, glossitis & stomatitis. Weakness, dizziness, ataxia, drowsiness, insomnia & mood changes, depression or confusion. Temporary moderate leukopenia, urethral discomfort, darkening of urine.
Pregnancy Category (US FDA)	Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). http://www.mims.com/Philippines/drug/info/Medgyl/?q=Other%20Antiprotozoal%20Agents&type=brief