furazolidone
| Indication & Dosage | Oral Giardiasis, Cholera Adult: 100 mg 4 times daily. Usual duration: 2-5 days, up to 7 days in some patients or 10 days for giardiasis. Child: 1.25 mg/kg 4 times daily, usually given for 2-5 days or up to 10 days for giardiasis. |
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| Administration | Should be taken with food. (Avoid food & beverage containing tyramine or tryptophan, eg alcohol, beer (incl alcohol-free beer), cheese, yoghurt. See lit for complete list.) | |||||||||||||||||
| Contraindications | Hypersensitivity, infants <1 mth. Alcohol. | |||||||||||||||||
| Special Precautions | Pregnancy, lactation, G6PD deficiency. | |||||||||||||||||
| Adverse Drug Reactions | Hypersensitivity,
hypoglycaemia, orthostatic hypotension, dizziness, drowsiness,
headache, malaise, nausea, vomiting, rash, fever, arthralgia, brown
urine, haemolytic anaemia. Potentially Fatal: Agranulocytosis. Hypertensive crisis with MAOIs. |
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| Drug Interactions | Disulfiram-like reaction with alcohol. Potential hypertensive crisis with sympathomimetics, tyramine-containing foods, levodopa. Potentially Fatal: Potentiation of MAOIs. Toxic psychosis with amitriptyline. |
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| Food Interaction | Reaction with foods rich in tyramine. | |||||||||||||||||
| Pregnancy Category (US FDA) |
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| Mechanism of Action | Furazolidone has a broad antibacterial spectrum which is active against susceptible organisms including E. coli, staphylococci, Giardia sp. and against salmonella, shigella, proteus, and V. cholerae. Its bactericidal action is by interfering with bacterial enzyme systems. Absorption: Poor (oral). Excretion: Urine (as active drug and metabolites).http://www.mims.com/Philippines/drug/info/furazolidone/?type=full&mtype=generic#Dosage |
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