miltefosine

Indication & Dosage	Oral Visceral leishmaniasis Adult: 100-150 mg daily for 28 days. Topical/Cutaneous Mycosis fungoides Adult: 6% solution applied 1-2 times daily. Topical/Cutaneous Skin metastases of breast cancer Adult: 6% solution applied 1-2 times daily.
Contraindications	Pregnancy, lactation, concurrent radiation therapy.
Special Precautions	Metastases grown over breast implants.
Adverse Drug Reactions	Oral: leukocytosis; thrombocytosis; GI irritation, nausea, vomiting, diarrhoea, constipation; ocular, hepatic, renal toxicity. Topical: pruritis; erythema; scaling; xerosis; tightness of the skin; dermatitis; pain; ulceration; necrosis.
Mechanism of Action	Miltefosine is a phospholipid derivative thought to work by disrupting cell-membrane function.